ColourSpace very deliberately uses exclusive modes for hardware connections.
This means that if drivers are being accessed by other software, ColourSpace will not connect.
If you have hardware connection issues, check for 3rd party programs that may be causing such problems.

For example, users have had issues with Displaycal/Argyll when installed on the same PC, preventing connection to displays and probes.
Even totally unrelated software can cause such issues, with Gigabyte Aorus Graphics Engine having proven to cause connection problems.
Manufacture specific software can also cause such issues if running in the background.
LG have confirmed that their Calibration Studio can potentially cause such issues, as can X-Rite's i1Profiler (and similar) software.

As a minimum, any 3rd party software should be prevented from running in the background, and a full uninstall of any 3rd party program may likely be required, including uninstalling any associated drivers, to enable ColourSpace to operate correctly.

Steve

Thanks for letting us know Steve!
I was hopping to use the same laptop for ColorSpace and X-Rite software which I use for print profiles. I have also drivers and some ancient software and spectros installed on this such as ProfileMaker, Spectrolino etc, i1iO with i1Pro2 etc.

Might worth keeping this thread updated with incompatible software. I will post my findings too once I receive my new probes.
(not sure if the forum supports sticky threads, but if so, this one worth to be sticky!)