I'm planning on getting a new Macbook Air to replace my old 2010 Macbook Pro. I'm currently running Lightspace on the 2010 using a dedicated Boot Camp partition, but when I get the Macbook Air, I would really prefer not to have to partition the precious space on the SSD for Boot Camp, just for the sake of running Lightspace. If I could run Lightspace in a Parallels or VMWare virtual machine while running OS X, that would be an ideal setup for me.

Are there any known issues with running Lightspace this way? I'll mostly be doing DIP profiling, so the patch generation wont be coming from the computer itself.

No known issues, and I know users are running LightSpace via Parallels and/or VMWare, so I guess it works fine.
Personally I use Windows, so can't comment on personal experience.

Steve