Hi Aaron. It works by hooking into Desktop Window Manager (DWM), so if that is running when you're in Win then it should work. Try it and let us know. But a lut is a lut is a lut. It's just a bunch of numbers to take an input to obtain an output. There is no sRGB/REC709 as such. Colourspace will profile your display so the input to the lut is known, and then CSpace will use that input to figure out the output P3 D65 G2.2 in your case, or Rec709 in most. The only thing you need to ensure is the format of the lut and CSpace does pretty well all, including either a cube or the eecolor format. This is the important part. So you can profile, create the lut, load it into the app and then verify all using CSpace on your Mac. If it has DWM running then I presume it would work. But P3 D65 gamma 2.2? CSpace will show you the capability of your display. If your display is poor you may need to use large profiles and the lut tools such as map space or fit space etc.
All this is presuming MAC colorsync is not active when in Windows! You will want to ensure the VCGT are aslo null before profiling.